Ontology highlight
ABSTRACT:
SUBMITTER: Goldstein A
PROVIDER: S-EPMC5362513 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Goldstein Alexa A Toro Patricia Valda PV Lee Justin J Silberstein John L JL Nakazawa Mary M Waters Ian I Cravero Karen K Chu David D Cochran Rory L RL Kim Minsoo M Shinn Daniel D Torquato Samantha S Hughes Robert M RM Pallavajjala Aparna A Carducci Michael A MA Paller Channing J CJ Denmeade Samuel R SR Kressel Bruce B Trock Bruce J BJ Eisenberger Mario A MA Antonarakis Emmanuel S ES Park Ben H BH Hurley Paula J PJ
Oncotarget 20170201 9
Somatic genetic alterations including copy number and point mutations in the androgen receptor (AR) are associated with resistance to therapies targeting the androgen/AR axis in patients with metastatic castration resistant prostate cancer (mCRPC). Due to limitations associated with biopsying metastatic lesions, plasma derived cell-free DNA (cfDNA) is increasingly being used as substrate for genetic testing. AR mutations detected by deep next generation sequencing (NGS) of cfDNA from patients wi ...[more]