Ontology highlight
ABSTRACT:
SUBMITTER: Koncar RF
PROVIDER: S-EPMC5362526 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Koncar Robert F RF Chu Zhengtao Z Romick-Rosendale Lindsey E LE Wells Susanne I SI Chan Timothy A TA Qi Xiaoyang X Bahassi El Mustapha EM
Oncotarget 20170201 9
Despite multimodal therapy with radiation and the DNA alkylating agent temozolomide (TMZ), malignant gliomas remain incurable. Up to 90% of grades II-III gliomas contain a single mutant isocitrate dehydrogenase 1 (IDH1) allele. IDH1 mutant-mediated transformation is associated with TMZ resistance; however, there is no clinically available means of sensitizing IDH1 mutant tumors to TMZ. In this study we sought to identify a targetable mechanism of TMZ resistance in IDH1 mutant tumors to enhance T ...[more]