Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC5362616 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Liu Chao C Huang Xuan X Werner Melanie M Broering Ruth R Ge Jun J Li Yongyin Y Liao Baolin B Sun Jian J Peng Jie J Lu Mengji M Hou Jinlin J Zhang Xiaoyong X
Frontiers in immunology 20170323
C-X-C-chemokine ligand 13 (CXCL13), the ligand for C-X-C chemokine receptor type 5 (CXCR5), is a major regulator of B-cell trafficking and plays an integral role in age-dependent clearance of hepatitis B virus (HBV) in the mouse model. However, the expression and function of CXCL13 in patients with chronic hepatitis B (CHB) remain unknown. By use of liver cell subpopulations isolated from CHB patients, we found that CXCL13 mRNA was abundantly expressed in Kupffer cells (KCs), but not in primary ...[more]