Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC5362808 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Wang Jinfeng J Zhang Lin L Pan Xiaoyan X Dai Bingling B Sun Ying Y Li Chuansheng C Zhang Jie J
Scientific reports 20170323
Recently, we have identified a biphenyl-aryl urea incorporated with salicylaldoxime (BPS-7) as an anti-angiogenesis agent. Herein, we disclosed a series of novel anti-angiogenesis agents with BPS-7 as lead compound through combining diarylureas with N-pyridin-2-ylcyclopropane carboxamide. Several title compounds exhibited simultaneous inhibition effects against three pro-angiogenic RTKs (VEGFR-2, TIE-2 and EphB4). Some of them displayed potent anti-proliferative activity against human vascular e ...[more]