Ontology highlight
ABSTRACT:
SUBMITTER: Diaconu I
PROVIDER: S-EPMC5363196 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Diaconu Iulia I Ballard Brandon B Zhang Ming M Chen Yuhui Y West John J Dotti Gianpietro G Savoldo Barbara B
Molecular therapy : the journal of the American Society of Gene Therapy 20170208 3
Immunotherapy with T cells expressing the chimeric antigen receptor (CAR) specific for the CD19 antigen (CD19.CAR-Ts) is a very effective treatment in B cell lymphoid malignancies. However, B cell aplasia and cytokine release syndrome (CRS) secondary to the infusion of CD19.CAR-Ts remain significant drawbacks. The inclusion of safety switches into the vector encoding the CAR is seen as the safest method to terminate the effects of CD19.CAR-Ts in case of severe toxicities or after achieving long- ...[more]