Ontology highlight
ABSTRACT:
SUBMITTER: Kolling M
PROVIDER: S-EPMC5363308 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kölling Malte M Kaucsar Tamas T Schauerte Celina C Hübner Anika A Dettling Angela A Park Joon-Keun JK Busch Martin M Wulff Xaver X Meier Matthias M Scherf Kristian K Bukosza Nóra N Szénási Gábor G Godó Mária M Sharma Amit A Heuser Michael M Hamar Peter P Bang Claudia C Haller Hermann H Thum Thomas T Lorenzen Johan M JM
Molecular therapy : the journal of the American Society of Gene Therapy 20170104 1
Diabetic nephropathy is the main cause of end-stage renal disease. MicroRNAs are powerful regulators of the genome, and global expression profiling revealed miR-21 to be among the most highly regulated microRNAs in kidneys of mice with diabetic nephropathy. In kidney biopsies of diabetic patients, miR-21 correlated with tubulointerstitial injury. In situ PCR analysis showed a specific enrichment of miR-21 in glomerular cells. We identified cell division cycle 25a (Cdc25a) and cyclin-dependent ki ...[more]