Ontology highlight
ABSTRACT:
SUBMITTER: Efthimiou O
PROVIDER: S-EPMC5363348 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Efthimiou Orestis O Welton Nicky N Samara Myrto M Leucht Stefan S Salanti Georgia G
Pharmaceutical statistics 20161205 2
Missing outcome data constitute a serious threat to the validity and precision of inferences from randomized controlled trials. In this paper, we propose the use of a multistate Markov model for the analysis of incomplete individual patient data for a dichotomous outcome reported over a period of time. The model accounts for patients dropping out of the study and also for patients relapsing. The time of each observation is accounted for, and the model allows the estimation of time-dependent rela ...[more]