Ontology highlight
ABSTRACT:
SUBMITTER: Selvaraj UM
PROVIDER: S-EPMC5363460 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Selvaraj Uma Maheswari UM Ortega Sterling B SB Hu Ruilong R Gilchrist Robert R Kong Xiangmei X Partin Alexander A Plautz Erik J EJ Klein Robyn S RS Gidday Jeffrey M JM Stowe Ann M AM
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160721 3
Repetitive hypoxic preconditioning creates long-lasting, endogenous protection in a mouse model of stroke, characterized by reductions in leukocyte-endothelial adherence, inflammation, and infarct volumes. The constitutively expressed chemokine CXCL12 can be upregulated by hypoxia and limits leukocyte entry into brain parenchyma during central nervous system inflammatory autoimmune disease. We therefore hypothesized that the sustained tolerance to stroke induced by repetitive hypoxic preconditio ...[more]