Ontology highlight
ABSTRACT:
SUBMITTER: Yokokura M
PROVIDER: S-EPMC5363467 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yokokura Masamichi M Terada Tatsuhiro T Bunai Tomoyasu T Nakaizumi Kyoko K Takebayashi Kiyokazu K Iwata Yasuhide Y Yoshikawa Etsuji E Futatsubashi Masami M Suzuki Katsuaki K Mori Norio N Ouchi Yasuomi Y
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160721 3
The presence of activated microglia in the brains of healthy elderly people is a matter of debate. We aimed to clarify the degree of microglial activation in aging and dementia as revealed by different tracers by comparing the binding potential (BP<sub>ND</sub>) in various brain regions using a first-generation translocator protein (TSPO) tracer [<sup>11</sup>C]( R)PK11195 and a second-generation tracer [<sup>11</sup>C]DPA713. The BP<sub>ND</sub> levels, estimated using simplified reference tiss ...[more]