Effects of voluntary exercise on structure and function of cortical microvasculature.

ABSTRACT: Aerobic activity has been shown highly beneficial to brain health, yet much uncertainty still surrounds the effects of exercise on the functioning of cerebral microvasculature. This study used two-photon fluorescence microscopy to examine cerebral hemodynamic alterations as well as accompanying geometric changes in the cortical microvascular network following five weeks of voluntary exercise in transgenic mice endogenously expressing tdTomato in vascular endothelial cells to allow visualization of microvessels irrespective of their perfusion levels. We found a diminished microvascular response to a hypercapnic challenge (10% FiCO₂) in running mice when compared to that in nonrunning controls despite commensurate increases in transcutaneous CO₂ tension. The flow increa

SUBMITTER: Dorr A 

PROVIDER: S-EPMC5363487 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature