Ontology highlight
ABSTRACT:
SUBMITTER: Mikosik A
PROVIDER: S-EPMC5363525 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Mikosik Anna A Jasiulewicz Aleksandra A Daca Agnieszka A Henc Izabella I Frąckowiak Joanna E JE Ruckemann-Dziurdzińska Katarzyna K Foerster Jerzy J Le Page Aurelie A Bryl Ewa E Fulop Tamas T Witkowski Jacek M JM
Oncotarget 20161101 47
The immune response is determined by the speed of the T cell reaction to antigens assured by a state of readiness for proliferation and cytokine secretion. Proliferation, apoptosis and motion of many cell types are controlled by cytoplasmic proteases - µ- and m-calpain - and their inhibitor calpastatin, together forming the "calpain-calpastatin system" (CCS), assumed to modify their targets only upon activation-dependent cytoplasmic Ca2+ increase. Contrastingly to this notion, using quantitative ...[more]