Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC5363529 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Zhang Liyuan L Yu Zhenlong Z Wang Yan Y Wang Xiaobo X Zhang Lianru L Wang Chao C Yue Qingxi Q Wang Xun X Deng Sa S Huo Xiaokui X Tian Xiangge X Huang Shanshan S Zhang Baojing B Ma Xiaochi X
Oncotarget 20161101 47
Gamabufotalin (CS-6) is a major bufadienolide of Chansu, which shows desirable metabolic stability and less adverse effect in cancer therapy. CS-6 treatment inhibited the proliferation of NSCLC in a nanomolar range. And CS-6 could induce G2/M cell cycle arrest and apoptosis in A549 cells. However, its molecular mechanism in antitumor activity remains poorly understood. We employed a quantitative proteomics approach to identify the potential cellular targets of CS-6, and found 38 possible target- ...[more]