Ontology highlight
ABSTRACT:
SUBMITTER: Si X
PROVIDER: S-EPMC5363646 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Si Xiaohui X Zhang Xiaoyun X Hao Xing X Li Yunan Y Chen Zizhen Z Ding Yahui Y Shi Hui H Bai Jie J Gao Yingdai Y Cheng Tao T Yang Feng-Chun FC Zhou Yuan Y
Oncotarget 20161101 47
Leukemia stem cells (LSCs) can resist available treatments that results in disease progression and/or relapse. To dissect the microRNA (miRNA) expression signature of relapse in acute myeloid leukemia (AML), miRNA array analysis was performed using enriched LSCs from paired bone marrow samples of an AML patient at different disease stages. We identified that miR-99a was significantly upregulated in the LSCs obtained at relapse compared to the LSCs collected at the time of initial diagnosis. We a ...[more]