Ontology highlight
ABSTRACT:
SUBMITTER: Barteczek P
PROVIDER: S-EPMC5363746 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Barteczek Philipp P Li Lexiao L Ernst Anne-Sophie AS Böhler Laura-Inés LI Marti Hugo H HH Kunze Reiner R
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160108 1
Hypoxia-inducible factors mediate adaptive responses to ischemia, among others, by induction of anti- and pro-survival genes. Thus, the impact of HIF on neuronal survival upon stroke is controversial. Therefore, neuron-specific knockout mice deficient for Hif1a and Hif2a were exposed to inspiratory hypoxia or ischemia-reperfusion injury. Both Hif1a- and Hif2a-deficient mice showed no altered infarct and edema size, suggesting that both HIF-α subunits might compensate for each other. Accordingly, ...[more]