Maternal high-fat diet influences outcomes after neonatal hypoxic-ischemic brain injury in rodents.
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ABSTRACT:
SUBMITTER: Barks JD
PROVIDER: S-EPMC5363747 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Maternal high-fat diet influences outcomes after neonatal hypoxic-ischemic brain injury in rodents.
Barks John D JD Liu Yiqing Y Shangguan Yu Y Djuric Zora Z Ren Jianwei J Silverstein Faye S FS
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160106 1
The typical US diet has >30% calories from fat; yet, typical laboratory diets contain 17% calories from fat. This disparity could confound the clinical relevance of findings in cerebral ischemia models. We compared outcomes after neonatal brain injury in offspring of rat dams fed standard low-fat chow (17% fat calories) or a higher fat diet (34% fat calories) from day 7 of pregnancy. On postnatal day 7, hypoxic-ischemic injury was induced by right carotid ligation, followed by 60, 75 or 90 min 8 ...[more]
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