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Oxygen challenge magnetic resonance imaging in healthy human volunteers.

ABSTRACT: Oxygen challenge imaging involves transient hyperoxia applied during deoxyhaemoglobin sensitive (T2*-weighted) magnetic resonance imaging and has the potential to detect changes in brain oxygen extraction. In order to develop optimal practical protocols for oxygen challenge imaging, we investigated the influence of oxygen concentration, cerebral blood flow change, pattern of oxygen administration and field strength on T2*-weighted signal. Eight healthy volunteers underwent multi-parametric magnetic resonance imaging including oxygen challenge imaging and arterial spin labelling using two oxygen concentrations (target FiO₂ of 100 and 60%) administered consecutively (two-stage challenge) at both 1.5T and 3T. There was a greater signal increase in grey matter compared to white matter during oxygen challenge (p?2?=?100% compared to FiO₂?=?60% in grey matter at both field strengths (p?2?=?100% during a single oxygen challenge. Imaging at both 1.5T and 3T is clinically feasible.

SUBMITTER: Dani KA

PROVIDER: S-EPMC5363753 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Oxygen challenge magnetic resonance imaging in healthy human volunteers.

Dani Krishna A KA Moreton Fiona C FC Santosh Celestine C Lopez Rosario R Brennan David D Schwarzbauer Christian C Goutcher Colin C O'Hare Kevin K Macrae I Mhairi IM Muir Keith W KW

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160119 1

Oxygen challenge imaging involves transient hyperoxia applied during deoxyhaemoglobin sensitive (T2*-weighted) magnetic resonance imaging and has the potential to detect changes in brain oxygen extraction. In order to develop optimal practical protocols for oxygen challenge imaging, we investigated the influence of oxygen concentration, cerebral blood flow change, pattern of oxygen administration and field strength on T2*-weighted signal. Eight healthy volunteers underwent multi-parametric magne ...[more]

PMID: 26787107

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Oxygen challenge magnetic resonance imaging in healthy human volunteers.

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Oxygen challenge magnetic resonance imaging in healthy human volunteers.

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