Ontology highlight
ABSTRACT:
SUBMITTER: Lilly CL
PROVIDER: S-EPMC5363758 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lilly Cameron L CL Villa Nancy Y NY Lemos de Matos Ana A Ali Haider M HM Dhillon Jess-Karan S JS Hofland Tom T Rahman Masmudur M MM Chan Winnie W Bogen Bjarne B Cogle Christopher C McFadden Grant G
Molecular therapy oncolytics 20161214
Allogeneic stem cell transplant-derived T cells have the potential to seek and eliminate sites of residual cancer that escaped primary therapy. Oncolytic myxoma virus (MYXV) exhibits potent anti-cancer efficacy against human cancers like multiple myeloma (MM) and can arm transplant-derived T cells to become more effective cancer killers in vitro and in an immunodeficient xenotransplant murine model. Here, we tested ex vivo MYXV virotherapy against residual murine MM in immunocompetent mice using ...[more]