Ontology highlight
ABSTRACT:
SUBMITTER: Mahoney JP
PROVIDER: S-EPMC5363957 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Current opinion in structural biology 20161118
G protein-coupled receptors (GPCRs) respond to extracellular stimuli and interact with several intracellular binding partners to elicit cellular responses, including heterotrimeric G proteins. Recent structural and biophysical studies have highlighted the dynamic nature of GPCRs and G proteins and have identified specific conformational changes important for receptor-mediated nucleotide exchange on Gα. While domain separation within Gα is necessary for GDP release, opening the inter-domain inter ...[more]