Ontology highlight
ABSTRACT:
SUBMITTER: Ikle JM
PROVIDER: S-EPMC5364067 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Iklé Jennifer M JM Tavares Andre L P AL King Marisol M Ding Hailei H Colombo Sophie S Firulli Beth A BA Firulli Anthony B AB Targoff Kimara L KL Yelon Deborah D Clouthier David E DE
Genesis (New York, N.Y. : 2000) 20170210 3
In gnathostomes, dorsoventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches is crucial for the development of hinged jaws. One of the key signals that mediate this process is Endothelin-1 (EDN1). Loss of EDN1 binding to the Endothelin-A receptor (EDNRA) results in loss of EDNRA signaling and subsequent facial birth defects in humans, mice and zebrafish. A rate-limiting step in this crucial signaling pathway is the conversion of immature EDN1 into a mature active form ...[more]