Ontology highlight
ABSTRACT:
SUBMITTER: Milan M
PROVIDER: S-EPMC5364455 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
ACS central science 20170208 3
Monosubstituted cycloalkanes undergo regio- and enantioselective aliphatic C-H oxidation with H<sub>2</sub>O<sub>2</sub> catalyzed by biologically inspired manganese catalysts. The reaction furnishes the corresponding ketones resulting from oxidation at C3 and C4 methylenic sites (K<sub>3</sub> and K<sub>4</sub>, respectively) leading to a chiral desymmetrization that proceeds with remarkable enantioselectivity (64% ee) but modest regioselectivity at C3 (K<sub>3</sub>/K<sub>4</sub> ≈ 2) for <i>t ...[more]