Superposition-free comparison and clustering of antibody binding sites: implications for the prediction of the nature of their antigen.
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ABSTRACT:
SUBMITTER: Di Rienzo L
PROVIDER: S-EPMC5364466 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Superposition-free comparison and clustering of antibody binding sites: implications for the prediction of the nature of their antigen.
Di Rienzo Lorenzo L Milanetti Edoardo E Lepore Rosalba R Olimpieri Pier Paolo PP Tramontano Anna A
Scientific reports 20170324
We describe here a superposition free method for comparing the surfaces of antibody binding sites based on the Zernike moments and show that they can be used to quickly compare and cluster sets of antibodies. The clusters provide information about the nature of the bound antigen that, when combined with a method for predicting the number of direct antibody antigen contacts, allows the discrimination between protein and non-protein binding antibodies with an accuracy of 76%. This is of relevance ...[more]
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