Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum.
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ABSTRACT:
SUBMITTER: Doan NT
PROVIDER: S-EPMC5364534 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum.
Doan Nhat Trung NT Engvig Andreas A Persson Karin K Alnæs Dag D Kaufmann Tobias T Rokicki Jaroslav J Córdova-Palomera Aldo A Moberget Torgeir T Brækhus Anne A Barca Maria Lage ML Engedal Knut K Andreassen Ole A OA Selbæk Geir G Westlye Lars T LT
Scientific reports 20170324
Recent efforts using diffusion tensor imaging (DTI) have documented white matter (WM) alterations in Alzheimer's disease (AD). The full potential of whole-brain DTI, however, has not been fully exploited as studies have focused on individual microstructural indices independently. In patients with AD (n = 79), mild (MCI, n = 55) and subjective (SCI, n = 30) cognitive impairment, we applied linked independent component analysis (LICA) to model inter-subject variability across five complementary DT ...[more]
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