Ontology highlight
ABSTRACT:
SUBMITTER: Keyes BE
PROVIDER: S-EPMC5364946 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Keyes Brice E BE Liu Siqi S Asare Amma A Naik Shruti S Levorse John J Polak Lisa L Lu Catherine P CP Nikolova Maria M Pasolli Hilda Amalia HA Fuchs Elaine E
Cell 20161101 5
Aged skin heals wounds poorly, increasing susceptibility to infections. Restoring homeostasis after wounding requires the coordinated actions of epidermal and immune cells. Here we find that both intrinsic defects and communication with immune cells are impaired in aged keratinocytes, diminishing their efficiency in restoring the skin barrier after wounding. At the wound-edge, aged keratinocytes display reduced proliferation and migration. They also exhibit a dampened ability to transcriptionall ...[more]