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Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding.

ABSTRACT: To provide a molecular insight for guiding polymer coating in surface science and nanotechnology, here we examined the structures of brushed polyethylene glycol(bPEG)- and phosphorylcholine(bPC)-grafted iron oxide nanoparticles and analyzed their protein avoiding properties. We show bPC as an advantageous biomimetic alternative to PEG in rendering stealth nanostructures.

SUBMITTER: Wang B

PROVIDER: S-EPMC5365087 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding.

Wang Bo B Blin Thomas T Käkinen Aleksandr A Ge Xinwei X Pilkington Emily H EH Quinn John F JF Whittaker Michael R MR Davis Thomas P TP Ke Pu Chun PC Ding Feng F

Polymer chemistry 20160923 45

To provide a molecular insight for guiding polymer coating in surface science and nanotechnology, here we examined the structures of brushed polyethylene glycol(bPEG)- and phosphorylcholine(bPC)-grafted iron oxide nanoparticles and analyzed their protein avoiding properties. We show bPC as an advantageous biomimetic alternative to PEG in rendering stealth nanostructures. ...[more]

PMID: 28348639

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