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Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding.


ABSTRACT: To provide a molecular insight for guiding polymer coating in surface science and nanotechnology, here we examined the structures of brushed polyethylene glycol(bPEG)- and phosphorylcholine(bPC)-grafted iron oxide nanoparticles and analyzed their protein avoiding properties. We show bPC as an advantageous biomimetic alternative to PEG in rendering stealth nanostructures.

SUBMITTER: Wang B 

PROVIDER: S-EPMC5365087 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding.

Wang Bo B   Blin Thomas T   Käkinen Aleksandr A   Ge Xinwei X   Pilkington Emily H EH   Quinn John F JF   Whittaker Michael R MR   Davis Thomas P TP   Ke Pu Chun PC   Ding Feng F  

Polymer chemistry 20160923 45


To provide a molecular insight for guiding polymer coating in surface science and nanotechnology, here we examined the structures of brushed polyethylene glycol(bPEG)- and phosphorylcholine(bPC)-grafted iron oxide nanoparticles and analyzed their protein avoiding properties. We show bPC as an advantageous biomimetic alternative to PEG in rendering stealth nanostructures. ...[more]

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