Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.
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ABSTRACT:
SUBMITTER: Ren Y
PROVIDER: S-EPMC5365359 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.
Ren Yulin Y Chen Wei-Lun WL Lantvit Daniel D DD Sass Ellen J EJ Shriwas Pratik P Ninh Tran Ngoc TN Chai Hee-Byung HB Zhang Xiaoli X Soejarto Djaja D DD Chen Xiaozhuo X Lucas David M DM Swanson Steven M SM Burdette Joanna E JE Kinghorn A Douglas AD
Journal of natural products 20161216 3
Three new (1-3) and two known (4 and 5) cytotoxic cardiac glycosides were isolated and characterized from a medicinal plant, Streblus asper Lour. (Moraceae), collected in Vietnam, with six new analogues and one known derivative (5a-g) synthesized from (+)-strebloside (5). A preliminary structure-activity relationship study indicated that the C-10 formyl and C-5 and C-14 hydroxy groups and C-3 sugar unit play important roles in the mediation of the cytotoxicity of (+)-strebloside (5) against HT-2 ...[more]
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