Acquisition of Rifampin Resistance in Pulmonary Tuberculosis.
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ABSTRACT:
SUBMITTER: Kayigire XA
PROVIDER: S-EPMC5365665 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Acquisition of Rifampin Resistance in Pulmonary Tuberculosis.
Kayigire Xavier A XA Friedrich Sven O SO van der Merwe Lize L Diacon Andreas H AH
Antimicrobial agents and chemotherapy 20170324 4
<i>Mycobacterium tuberculosis</i> strains with spontaneous mutations conferring resistance to rifampin (RIF) are exceedingly rare, and fixed drug combinations typically prevent augmentation of resistance to single drugs. Fourteen newly diagnosed tuberculosis patients were treated with RIF alone for 14 days, and bacterial loads, including mutation frequencies, were determined. A statistical model estimated that 1% of the remaining viable mycobacteria could be RIF resistant after 30 days of monoth ...[more]
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