Ontology highlight
ABSTRACT:
SUBMITTER: Howard JJ
PROVIDER: S-EPMC5365667 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Howard James J JJ Sturge Carolyn R CR Moustafa Dina A DA Daly Seth M SM Marshall-Batty Kimberly R KR Felder Christina F CF Zamora Danniel D Yabe-Gill Marium M Labandeira-Rey Maria M Bailey Stacey M SM Wong Michael M Goldberg Joanna B JB Geller Bruce L BL Greenberg David E DE
Antimicrobial agents and chemotherapy 20170324 4
<i>Pseudomonas aeruginosa</i> is a highly virulent, multidrug-resistant pathogen that causes significant morbidity and mortality in hospitalized patients and is particularly devastating in patients with cystic fibrosis. Increasing antibiotic resistance coupled with decreasing numbers of antibiotics in the developmental pipeline demands novel antibacterial approaches. Here, we tested peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs), which inhibit translation of complementary mRN ...[more]