Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.
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ABSTRACT:
SUBMITTER: Bulman ZP
PROVIDER: S-EPMC5365695 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Influence of <i>rhlR</i> and <i>lasR</i> on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.
Bulman Zackery P ZP Ly Neang S NS Lenhard Justin R JR Holden Patricia N PN Bulitta Jürgen B JB Tsuji Brian T BT
Antimicrobial agents and chemotherapy 20170324 4
The impact of quorum sensing on polymyxin and azithromycin pharmacodynamics was assessed in <i>Pseudomonas aeruginosa</i> PAO1 and an isogenic <i>rhlR</i>/<i>lasR</i> double knockout. For polymyxin B, greater killing against the <i>rhlR</i>/<i>lasR</i> knockout than against PAO1 was observed at 10<sup>8</sup> CFU/ml (polymyxin B half-maximal effective concentration [EC<sub>50</sub>], 5.61 versus 12.5 mg/liter, respectively; <i>P</i> < 0.005). Polymyxin B combined with azithromycin (256 mg/liter) ...[more]
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