Ontology highlight
ABSTRACT:
SUBMITTER: Smith MJ
PROVIDER: S-EPMC5365720 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Smith Michael J MJ Gonzalez Daniel D Goldman Jennifer L JL Yogev Ram R Sullivan Janice E JE Reed Michael D MD Anand Ravinder R Martz Karen K Berezny Katherine K Benjamin Daniel K DK Smith P Brian PB Cohen-Wolkowiez Michael M Watt Kevin K
Antimicrobial agents and chemotherapy 20170324 4
Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data for obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from three separate trials. A total of 420 samples from 220 children, 76 of whom had a body mass index greater than or equal to the 95th percentile for age, were included in the analysis. ...[more]