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Nanoindentation analysis of the micromechanical anisotropy in mouse cortical bone.

ABSTRACT: Studies investigating micromechanical properties in mouse cortical bone often solely focus on the mechanical behaviour along the long axis of the bone. Therefore, data on the anisotropy of mouse cortical bone is scarce. The aim of this study is the first-time evaluation of the anisotropy ratio between the longitudinal and transverse directions of reduced modulus and hardness in mouse femurs by using the nanoindentation technique. For this purpose, nine 22-week-old mice (C57BL/6) were sacrificed and all femurs extracted. A total of 648 indentations were performed with a Berkovich tip in the proximal (P), central (C) and distal (D) regions of the femoral shaft in the longitudinal and transverse directions. Higher values for reduced modulus are obtained for indentations in the longitudinal direction, with anisotropy ratios of 1.72?±?0.40 (P), 1.75?±?0.69 (C) and 1.34?±?0.30 (D). Hardness is also higher in the longitudinal direction, with anisotropic ratios of 1.35?±?0.27 (P), 1.35?±?0.47 (C) and 1.17?±?0.19 (D). We observed a significant anisotropy in the micromechanical properties of the mouse femur, but the correlation for reduced modulus and hardness between the two directions is low (r2?

SUBMITTER: Casanova M

PROVIDER: S-EPMC5367284 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Nanoindentation analysis of the micromechanical anisotropy in mouse cortical bone.

Casanova Michele M Balmelli Anna A Carnelli Davide D Courty Diana D Schneider Philipp P Müller Ralph R

Royal Society open science 20170222 2

Studies investigating micromechanical properties in mouse cortical bone often solely focus on the mechanical behaviour along the long axis of the bone. Therefore, data on the anisotropy of mouse cortical bone is scarce. The aim of this study is the first-time evaluation of the anisotropy ratio between the longitudinal and transverse directions of reduced modulus and hardness in mouse femurs by using the nanoindentation technique. For this purpose, nine 22-week-old mice (C57BL/6) were sacrificed ...[more]

PMID: 28386450

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Dataset Information

Nanoindentation analysis of the micromechanical anisotropy in mouse cortical bone.

Publications

Nanoindentation analysis of the micromechanical anisotropy in mouse cortical bone.

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