Ontology highlight
ABSTRACT:
SUBMITTER: Friend R
PROVIDER: S-EPMC5367738 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Friend Reed R Bhutani Manisha M Voorhees Peter M PM Usmani Saad Z SZ
Drug design, development and therapy 20170320
Elotuzumab is one of the first monoclonal antibodies to be approved for the treatment of multiple myeloma. It is a humanized immunoglobulin G kappa (IgGκ) antibody that targets signaling lymphocytic activation molecule family member 7 (SLAMF7), a surface marker that is highly expressed on normal and malignant plasma cells. This review summarizes the preclinical and clinical data that led to the approval of elotuzumab, along with a discussion on the ongoing and future clinical investigations. ...[more]