Ontology highlight
ABSTRACT:
SUBMITTER: Glebov OO
PROVIDER: S-EPMC5368346 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Glebov Oleg O OO Jackson Rachel E RE Winterflood Christian M CM Owen Dylan M DM Barker Ellen A EA Doherty Patrick P Ewers Helge H Burrone Juan J
Cell reports 20170301 11
The active zone (AZ) matrix of presynaptic terminals coordinates the recruitment of voltage-gated calcium channels (VGCCs) and synaptic vesicles to orchestrate neurotransmitter release. However, the spatial organization of the AZ and how it controls vesicle fusion remain poorly understood. Here, we employ super-resolution microscopy and ratiometric imaging to visualize the AZ structure on the nanoscale, revealing segregation between the AZ matrix, VGCCs, and putative release sites. Long-term blo ...[more]