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Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.


ABSTRACT: BACKGROUND:Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits. METHODS:For each of 60 complex diseases/traits with publicly available genome-wide significant association data, the lead genetic variant per independent locus was extracted and a genetic score was calculated for each disease/trait as the weighted sum of risk alleles. The association with AMD was estimated based on 16,144 AMD cases and 17,832 controls using logistic regression. RESULTS:Of the respective disease/trait variance, the 60 genetic scores explained on average 4.8% (0.27-20.69%) and 16 of them were found to be significantly associated with AMD (Q-values?

SUBMITTER: Grassmann F 

PROVIDER: S-EPMC5368911 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.

Grassmann Felix F   Kiel Christina C   Zimmermann Martina E ME   Gorski Mathias M   Grassmann Veronika V   Stark Klaus K   Heid Iris M IM   Weber Bernhard H F BH  

Genome medicine 20170327 1


<h4>Background</h4>Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits.<h4>Methods</h4>For each of 60 complex diseases/traits with publicly available genome-wide significant association data, the lead geneti  ...[more]

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