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5?-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis.


ABSTRACT:

Background

5?-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5?-reductase activity in PCOS subjects and the relationship between 5?-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely unknown.

Methods

We performed a meta-analysis to examine 5?-reductase activity in women with PCOS; exploratory subgroup analyses were also performed.

Results

Five articles (with 356 cases and 236 controls) reporting 5?-reductase activity in patients with PCOS were selected for the meta-analysis. We observed significantly higher ratios of 5?THF/THF (5?-reduced tetrahydrocortisol to 5?-reduced tetrahydrocortisol) and An/Et (androsteroneto/etiocholanolone) levels, which were used to assess 5?-reductase activity, among the patients with PCOS, [standardized mean differences (SMD) =0.43, 95%confidence intervals (95%CI) =0.25-0.61, P?2?=?89% and P?Conclusions5?-reductase activity was enhanced in women with PCOS. Increased 5?-reductase activity in patients with PCOS was related to IR.

SUBMITTER: Wu C 

PROVIDER: S-EPMC5369013 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Publications

5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Wu Chuyan C   Wei Ke K   Jiang Zhongli Z  

Reproductive biology and endocrinology : RB&E 20170327 1


<h4>Background</h4>5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely unknown.<h4>Methods</h4>We performed a meta-analysis to examine 5α-reductase activity in women with PCOS; exploratory subgroup analyses were also performed.<h4>Results</h4>Five articles (with 356 case  ...[more]

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