Ontology highlight
ABSTRACT:
SUBMITTER: Billaud EMF
PROVIDER: S-EPMC5369547 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chemical science 20161007 2
Pretargeted PET imaging has emerged as an effective two-step <i>in vivo</i> approach that combines the superior affinity and selectivity of antibodies with the rapid pharmacokinetics and favorable dosimetry of smaller molecules radiolabeled with short-lived radionuclides. This approach can be based on the bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) reaction between tetrazines and <i>trans</i>-cyclooctene (TCO) derivatives. We aimed to develop new [<sup>18</sup>F]TCO-dienophiles wit ...[more]