Ontology highlight
ABSTRACT:
SUBMITTER: Lopes-Aguiar L
PROVIDER: S-EPMC5369956 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lopes-Aguiar Leisa L Costa Ericka Francislaine Dias EF Nogueira Guilherme Augusto Silva GA Lima Tathiane Regine Penna TR Visacri Marília Berlofa MB Pincinato Eder Carvalho EC Calonga Luciane L Mariano Fernanda Viviane FV de Almeida Milani Altemani Albina Messias AM Altemani João Maurício Carrasco JM Coutinho-Camillo Cláudia Malheiros CM Ribeiro Alves Maria Almerinda Vieira Fernandes MA Moriel Patrícia P Ramos Celso Dario CD Chone Carlos Takahiro CT Lima Carmen Silvia Passos CS
Oncotarget 20170301 10
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation. Patients with XPC c.2815AC or CC and XPD c.934GA or AA genotypes had 0.20 and 0.38 less chances of presenting moderate/severe ototoxicity and nausea, respectively. Patients with XP ...[more]