Ontology highlight
ABSTRACT:
SUBMITTER: Zhong W
PROVIDER: S-EPMC5370004 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zhong Weilong W Chen Shuang S Zhang Qiang Q Xiao Ting T Qin Yuan Y Gu Ju J Sun Bo B Liu Yanrong Y Jing Xiangyan X Hu Xuejiao X Zhang Peng P Zhou Honggang H Sun Tao T Yang Cheng C
Oncotarget 20170301 10
Doxycycline have been reported to exert anti-cancer activity and have been assessed as anti-cancer agents in clinical trials. However, the direct targets of doxycycline in cancer cells remain unclear. In this study, we used a chemical proteomics approach to identify the Protease-activated receptor 1 (PAR1) as a specific target of inhibition of doxycycline. Binding assays and single-molecule imaging assays were performed to confirm the inhibition of doxycycline to PAR1. The effect of doxycycline ...[more]