Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer.
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ABSTRACT:
SUBMITTER: Shi L
PROVIDER: S-EPMC5370071 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer.
Shi Lingyi L Zheng Hailun H Hu Wanle W Zhou Bin B Dai Xuanxuan X Zhang Yi Y Liu Zhiguo Z Wu Xiaoping X Zhao Chengguang C Liang Guang G
OncoTargets and therapy 20170323
Niclosamide, an anthelmintic drug approved by the US Food and Drug Administration against cestodes, is used to treat tapeworm infection. In this study, we show that niclosamide can potentially inhibit signal transducer and activator of transcription 3 (STAT3) in colon cancer cell lines. Combined inhibition of epidermal growth factor receptor and STAT3 by erlotinib and niclosamide synergistically induces apoptosis and antiproliferation in colon cancer cell lines. Our findings suggest that erlotin ...[more]
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