Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis.

ABSTRACT: Importance:There is growing interest in the role of nutrition in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS). Objective:To evaluate the associations between nutrients, individually and in groups, and ALS function and respiratory function at diagnosis. Design, Setting, and Participants:A cross-sectional baseline analysis of the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, 2013, at 16 ALS clinics throughout the United States among 302 patients with ALS symptom duration of 18 months or less. Exposures:Nutrient intake, measured using a modified Block Food Frequency Questionnaire (FFQ). Main Outcomes and Measures:Amyotrophic lateral sclerosis function, measured using the ALS Functional Rating Scale-Revised (ALSFRS-R), and respiratory function, measured using percentage of predicted forced vital capacity (FVC). Results:Baseline data were available on 302 patients with ALS (median age, 63.2 years [interquartile range, 55.5-68.0 years]; 178 men and 124 women). Regression analysis of nutrients found that higher intakes of antioxidants and carotenes from vegetables were associated with higher ALSFRS-R scores or percentage FVC. Empirically weighted indices using the weighted quantile sum regression method of "good" micronutrients and "good" food groups were positively associated with ALSFRS-R scores (? [SE], 2.7 [0.69] and 2.9 [0.9], respectively) and percentage FVC (? [SE], 12.1 [2.8] and 11.5 [3.4], respectively) (all P?

SUBMITTER: Nieves JW 

PROVIDER: S-EPMC5370581 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature