Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population.

ABSTRACT:

Background

Angiotensinogen (AGT) enzyme comprises a vital module of RAAS system that effectively controls the blood pressure and related cardiovascular functions. Ample association studies have reported the importance of AGT variants in cardiovascular and non-cardiovascular adversities. But lately, owing to the complexity of the many anomalies, the haplotype based examination of genetic variation that facilitates the identification of polymorphic sites which are located in the vicinity of the causative polymorphic site, gets greater appreciation.

Methods

In the present study, we have done genotype and haplotype analysis of AGT gene in reference to hypertension to confirm the association of the two in an Indian population. To accomplish this, we performed candidate SNPs analy

SUBMITTER: Purkait P 

PROVIDER: S-EPMC5371191 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature