Investigating the nucleic acid interactions of histone-derived antimicrobial peptides.
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ABSTRACT:
SUBMITTER: Sim S
PROVIDER: S-EPMC5371511 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Investigating the nucleic acid interactions of histone-derived antimicrobial peptides.
Sim Sukin S Wang Penny P Beyer Brittany N BN Cutrona Kara J KJ Radhakrishnan Mala L ML Elmore Donald E DE
FEBS letters 20170301 5
While many antimicrobial peptides (AMPs) disrupt bacterial membranes, some translocate into bacteria and interfere with intracellular processes. Buforin II and DesHDAP1 are thought to kill bacteria by interacting with nucleic acids. Here, molecular modeling and experimental measurements are used to show that neither nucleic acid binding peptide selectively binds DNA sequences. Simulations and experiments also show that changing lysines to arginines enhances DNA binding, suggesting that including ...[more]
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