Ontology highlight
ABSTRACT:
SUBMITTER: Okamoto CK
PROVIDER: S-EPMC5371845 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Okamoto Cinthya Kimori CK van den Berg Carmen W CW Masashi Mizuno M Gonçalves-de-Andrade Rute M RM Tambourgi Denise V DV
Toxins 20170302 3
Envenomation by <i>Loxosceles</i> spider can result in two clinical manifestations: cutaneous and systemic loxoscelism, the latter of which includes renal failure. Although incidence of renal failure is low, it is the main cause of death, occurring mainly in children. The sphingomyelinase D (SMase D) is the main component in <i>Loxosceles</i> spider venom responsible for local and systemic manifestations. This study aimed to investigate the toxicity of <i>L. intermedia</i> venom and SMase D on k ...[more]