Ontology highlight
ABSTRACT:
SUBMITTER: Jones DS
PROVIDER: S-EPMC5372219 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Jones Douglas S DS Jenney Anne P AP Swantek Jennifer L JL Burke John M JM Lauffenburger Douglas A DA Sorger Peter K PK
Nature chemical biology 20161031 1
Activation of synovial fibroblasts (SFs) contributes to rheumatoid arthritis (RA) by damaging synovial membranes and generating inflammatory cytokines that recruit immune cells to the joint. In this paper we profile cytokine secretion by primary human SFs from healthy tissues and from donors with RA and show that SF activation by TNF, IL-1α, and polyinosinic-polycytidylic acid (Poly(I:C)) cause secretion of multiple cytokines found at high levels in RA synovial fluids. We used interaction multip ...[more]