A genome-wide association study reveals a locus for bilateral iridal hypopigmentation in Holstein Friesian cattle.

ABSTRACT:

Background

Eye pigmentation abnormalities in cattle are often related to albinism, Chediak-Higashi or Tietz like syndrome. However, mutations only affecting pigmentation of coat color and eye have also been described. Herein 18 Holstein Friesian cattle affected by bicolored and hypopigmented irises have been investigated.

Results

Affected animals did not reveal any ophthalmological or neurological abnormalities besides the specific iris color differences. Coat color of affected cattle did not differ from controls. Histological examination revealed a reduction of melanin pigment in the iridal anterior border layer and stroma in cases as cause of iris hypopigmentation. To analyze the genetics of the iris pigmentation differences, a genome-wide association study was performed u

SUBMITTER: Hollmann AK 

PROVIDER: S-EPMC5372310 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature