Ontology highlight
ABSTRACT:
SUBMITTER: Bachurin SO
PROVIDER: S-EPMC5372361 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20170330
A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and carbazole derivatives was synthesized and investigated. Compounds of these series were found to interact with a group of targets that play an important role in the development of this type of diseases. First of all, these compounds selectively inhibit butyrylcholinesterase, block NMDA receptors containing NR2B subunits w ...[more]