Ontology highlight
ABSTRACT:
SUBMITTER: Andrew AS
PROVIDER: S-EPMC5372551 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Andrew Angeline S AS Baron John A JA Butterly Lynn F LF Suriawinata Arief A AA Tsongalis Gregory J GJ Robinson Christina M CM Amos Christopher I CI
International journal of molecular sciences 20170302 3
Although serrated polyps were historically considered to pose little risk, it is now understood that progression down the serrated pathway could account for as many as 15%-35% of colorectal cancers. The sessile serrated adenoma/polyp (SSA/P) is the most prevalent pre-invasive serrated lesion. Our objective was to identify the CpG loci that are persistently hyper-methylated during serrated carcinogenesis, from the early SSA/P lesion through the later cancer phases of neoplasia development. We que ...[more]