Ontology highlight
ABSTRACT:
SUBMITTER: Magdalon J
PROVIDER: S-EPMC5372671 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Magdalon Juliana J Sánchez-Sánchez Sandra M SM Griesi-Oliveira Karina K Sertié Andréa L AL
International journal of molecular sciences 20170318 3
Whereas autism spectrum disorder (ASD) exhibits striking heterogeneity in genetics and clinical presentation, dysfunction of mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway has been identified as a molecular feature common to several well-characterized syndromes with high prevalence of ASD. Additionally, recent findings have also implicated mTORC1 signaling abnormalities in a subset of nonsyndromic ASD, suggesting that defective mTORC1 pathway may be a potential converging m ...[more]