Ontology highlight
ABSTRACT:
SUBMITTER: Sweeney NL
PROVIDER: S-EPMC5372984 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Sweeney Noreena L NL Lipker Lauren L Hanson Alicia M AM Bohl Chris J CJ Engel Katie E KE Kalous Kelsey S KS Stemper Mary E ME Sem Daniel S DS Schwan William R WR
Antibiotics (Basel, Switzerland) 20170128 1
The thioredoxin/thioredoxin reductase system (Trx/TrxR) is an attractive drug target because of its involvement in a number of important physiological processes, from DNA synthesis to regulating signal transduction. This study describes the finding of pyrazolone compounds that are active against <i>Staphylococcus aureus</i>. Initially, the project was focused on discovering small molecules that may have antibacterial properties targeting the <i>Mycobacterium tuberculosis</i> thioredoxin reductas ...[more]