Ontology highlight
ABSTRACT:
SUBMITTER: Clevenger KD
PROVIDER: S-EPMC5373092 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
ACS chemical biology 20170215 3
Siderophore biosynthesis by Pseudomonas aeruginosa enhances virulence and represents an attractive drug target. PvdQ functions in the type-1 pyoverdine biosynthetic pathway by removing a myristoyl anchor from a pyoverdine precursor, allowing eventual release from the periplasm. A circularly permuted version of PvdQ bypasses the self-processing step of this Ntn-hydrolase and retains the activity, selectivity, and structure of wild-type PvdQ, as revealed by a 1.8 Å resolution X-ray crystal structu ...[more]