Ontology highlight
ABSTRACT:
SUBMITTER: Derler I
PROVIDER: S-EPMC5373433 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Derler Isabella I Jardin Isaac I Stathopulos Peter B PB Muik Martin M Fahrner Marc M Zayats Vasilina V Pandey Saurabh K SK Poteser Michael M Lackner Barbara B Absolonova Marketa M Schindl Rainer R Groschner Klaus K Ettrich Rüdiger R Ikura Mitsu M Romanin Christoph C
Science signaling 20160126 412
STIM1 (stromal interaction molecule 1) and Orai proteins are the essential components of Ca(2+) release-activated Ca(2+) (CRAC) channels. We focused on the role of cholesterol in the regulation of STIM1-mediated Orai1 currents. Chemically induced cholesterol depletion enhanced store-operated Ca(2+) entry (SOCE) and Orai1 currents. Furthermore, cholesterol depletion in mucosal-type mast cells augmented endogenous CRAC currents, which were associated with increased degranulation, a process that re ...[more]